摘 要：肿瘤转移是恶性肿瘤的重要生物学特征，是导致患者死亡的主要原因。
因此了解影响肿瘤转移的因素，对于肿瘤的发生发展具有十分重要的作用。
众所周知，肿瘤转移是一个多因素、多步骤的综合结果，本文主要从影响肿瘤的诸多因素出发，如肿瘤微环境、上皮间质转化、肿瘤干细胞、基因调控等，探讨其对肿瘤转移的影响。
与此同时，我们还发现低热对于肿瘤转移也有一定影响，但这方面的研究文献极少，而临床肿瘤患者往往伴随着低热症状，因此就该问题进行深入研究很有必要，究竟临床低热症状对于肿瘤转移有没有影响？目前没有明确定论，而这成为了我们的一个研究热点。
本文就影响肿瘤转移的部分因素及低热对肿瘤转移的影响作一综述，为指导临床提供重要参考。
关键词：肿瘤转移；肿瘤微环境；上皮间质转化；低热Research on low-heat on tumor metastasis Abstract：Tumor metastasis is an important biological characteristics of malignant tumors,and is the leading cause of death in patients. Therefore, understanding the impact factors of tumor metastasis for tumor development has a very important role. As we all know, tumor metastasis is a multi-factor, multi-step synthesis results. This article from the many factors that affect tumor departure investigate its effect on tumor metastasis, for example, tumor microenvironment, EMT, tumor stem cells, gene regulation, etc. At the same time, we also found that fever also have some impact on tumor metastasis, but this aspect has very little research literature. whats more clinical tumor is often accompanied by fever symptoms, so further research on the issue is necessary, whether the clinical symptoms of the fever tumor metastasis have any effect? There is no clear conclusion, which has become one of our research focus. In this paper, some of the factors affecting low heat and metastasis of tumor metastasis in reviewed, providing an important reference for the clinical.Keywords: tumor metastasis; tumor microenvironment; epithelial-mesenchymal transition; fever1．肿瘤转移肿瘤转移是指恶性的肿瘤细胞从原发部位脱落，经淋巴系统，血管系统或者体腔等途径，到达其他不相连续的部位继续生长，形成相同性质的肿瘤的过程，是肿瘤发生发展的一部分。
肿瘤分为良性肿瘤和恶性肿瘤两大类。
良性肿瘤分化比较完全，生长缓慢，不易发生肿瘤的转移。
而恶性肿瘤分化不好，异型性高，相对较容易发生转移，而肿瘤转移一般是以直接转移、淋巴系统转移、血管系统转移或种植等方式进行。
肿瘤转移是导致患者死亡的主要原因，在进行临床研究时发现，60% 以上检查出恶性肿瘤的患者在临床查出肿瘤存在时已经发生了转移[1]，并且通过数据统计超过90%的患有恶性肿瘤的患者死于肿瘤转移[2]。
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