固体剂量药物的抗儿童开启包装文献综述

 2022-02-28 11:02

固体剂量药物的抗儿童开启包装

Lalji Baldaniya、Vaibhav Shah、Malav Maniar、Mukesh Gohel、Vaishali Thakkar、Tejal Gandhi

摘 要

口服固体药物的主要包装形式是泡罩包装和条状包装,然后包装在纸箱中。在没有人监督的情况下,那些设法打开这些盒子的孩子,很有可能因误食药物而处于危险之中。 一个抗童包装通常需要一个特殊的技巧才能打开。我们的目的是设计和验证具有独特特性的创新抗儿童开启包装系统的性能,所使用的材料是塑料、点击锁定系统、和泡罩包装。测试内容是让100名健康儿童以及100名健康成人分别打开一个包装,100名健康儿童分为三组:30名42-44个月的儿童、40名45-48个月的儿童和30名49-51个月的儿童;100名健康成年人也分为3组:25名成人18-40岁,25名成人40-59岁,50名成人60-70岁。结果显示,只有6%的儿童成功打开防儿童开启包装,而94%的儿童在5分钟内未打开CRP。对于成年人,96%的人成功地打开了包装,而没有造成任何困难。 成功开发的抗儿童开启包装原型,可用于医药产品的包装。抗儿童开启包装阻止了儿童接触药物包装系统,从而远离任何的毒物危险。

关键词:抗童包装;条形包装;可重启包装

Peppermint hard candy packaging design with Kansei

Engineering

ABSTRACT

The major oral solid medicines are sold in blister and strips packaging, which are packaged in a carton box. Children, who manage to open such boxes, while unsupervised, are in great danger of being poisoned by swallowing the contents. A CRP usually requires a special trick to open it. The aim was to design and validate the performance of innovative CRP system with unique features. Materials used were the plastic grade, click lock system, and blister pack. The test conducted on test panels of 100 healthy children between 42 and 51 months were asked to open a pack. Each panel divided into 3 groups, viz. 30 children of 42–44 months, 40 children 45–48 months, and 30 children 49–51 months. The panel of 100 healthy adults divided into 3 groups, viz. 25 adults 18–40 years, 25 adults 40–59 years, and 50 adults 60–70 years. Results shown only 6% of children succeeded to open CRP, while 94% failed to open CRP within 5 min. In the case of adults, 96% succeeded to open CRP without imposing any difficulties. There was a successful development of a prototype of CRP, which can used for the packaging of pharmaceutical products. CRP deprived children to have access of medicated packaging system, which resulted in devoid of any poisonous effect to the children.

Keywords: Child-resistant packaging (CRP); Strip packaging ; Re-closable packaging

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