摘要：糖尿病心肌病是指由糖尿病直接引起的心脏结构和功能的病理性改变。
未折叠蛋白反应UPR是内质网应激时心肌细胞启动一系列与蛋白质分泌相关的适应性反应，以恢复细胞内环境的稳态。
但是，持久或剧烈的内质网应激，内质网稳态不能恢复，由促进生存转为促进凋亡。
UPR 信号通路异常以及导致 UPR 信号通路超负荷的病理因素均在糖尿病心肌病进程中发挥关键作用。
故通过干预UPR治疗糖尿病心肌病正在受到越来越多的关注。
关键词：内质网应激；未折叠蛋白反应；糖尿病心肌病Effect of unfolded protein reaction on the occurrence and development of diabetic cardiomyopathyWU Zhi gui (1. Department of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province, China postcode 210000)Abstract： Diabetic cardiomyopathy refers to the pathological changes of cardiac structure and function caused directly by diabetes mellitus. Unfolded protein response (UPR) is a series of adaptive responses related to protein secretion initiated by myocardial cells under endoplasmic reticulum stress to restore homeostasis of the cellular environment. However, persistent or intense endoplasmic reticulum stress, endoplasmic reticulum homeostasis can not be restored, from promoting survival to promoting apoptosis. The abnormal UPR signaling pathway and the pathological factors leading to the overload of UPR signaling pathway play a key role in the process of diabetic cardiomyopathy. Therefore, the treatment of diabetic cardiomyopathy by UPR intervention is receiving more and more attention.Key words：endoplasmic reticulum stress; unfolded protein response; diabetic cardiomyopathy糖尿病心肌病是一种特殊的心脏疾病，与其他类型的心肌病相比，其特殊性在于早期会出现心脏舒张功能障碍。
在糖尿病心肌病后期，由于机体持续的糖脂代谢紊乱状态，心肌细胞受到高血糖和高血脂等病理因素的渐进式损伤，会出现临床症状明显的心脏功能病变。
大量的研究表明，心肌细胞内质网应激诱发的未折叠蛋白反应（UPR）对细胞功能有着重要的调节作用。
因此，通过干预UPR治疗糖尿病心肌病正在受到越来越多的关注。
一、ER与ERS内质网（ER）是真核细胞中蛋白质合成、折叠与分泌的重要细胞器。
